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KMID : 1191420140130010019
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Korean Journal of Optometry and Vision Science
2014 Volume.13 No. 1 p.19 ~ p.23
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Intraocular Pressure Lowering Effect of Tafluprost in Korean Glaucoma and Ocular Hypertension Patients
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Kyung Hak-Su
Lee Seung-Jae
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Abstract
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Purpose: To investigate intraocular pressure (IOP) lowering effect of Tafluprost in Korean glaucoma and ocular hypertension patients.
Methods: Seventy eight patients, one hundred thirty five eyes, diagnosed with glaucoma and ocular hypertension received Tafluprost once daily. We analyzed IOP and its change from baseline at week 1, month 1, moth 3, month 6 and month 9.
Results: Among all 135 eyes, 117 eyes had normal tension glaucoma (NTG), 11 eyes had primary open angle glaucoma (POAG), and 7 eyes had ocular hypertension (OHT). The average IOP was 16.0 ± 3.7 mm Hg at baseline, 12.5 ± 2.5 mm Hg (least squares [LS] mean difference: -4.6 mm Hg; p < 0.0001) after 1 week, 12.6 ± 2.7 mm Hg (-3.2 mm Hg; p < 0.0001) after 1 month, 12.4 ± 3.0 mm Hg (-2.8 mm Hg; p < 0.0001) after 3 months, 12.8 ± 3.0 mm Hg (-3.9 mm Hg; p <0.0001) after 6 months and 12.0 ± 2.5 mm Hg (-2.7 mm Hg; p < 0.0001) after 9 months. All measurements showed a statistically significant IOP reduction.
Conclusions: Tafluprost was effective in IOP lowering effects up to 9 months in Korean glaucoma and ocular hypertension patients.
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KEYWORD
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Glaucoma, Intraocular pressure reduction, Prostaglandin analogs, Tafluprost
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